When the Rams (7-2) go on the road to face the 49ers (3-5) to finish NFL Week 10 on “Monday Night Football” (8:15 p.m. ET, ESPN, ESPN2), they will be looking to create some further separation in the NFC West standings. Los Angeles and San Francisco also will renew the rivalry between NFC champion coaches Sean McVay and Kyle Shanahan.
The Rams have added wide receiver Odell Beckham Jr. to their passing offense with Matthew Stafford and Cooper Kupp. The 49ers have shown more through the air with George Kittle returning to help Jimmy Garoppolo, Deebo Samuel and Brandon Aiyuk. Both teams also will look to run the ball well with Darrell Henderson and rookie Elijah Mitchell, respectively.
Here’s everything to know about betting on 49ers vs. Rams in Week 10, including updated odds, trends and our prediction for “Monday Night Football.”
49ers vs. Rams odds for Monday Night Football
- Spread: Rams by 3.5
- Over/under: 50.5
- Moneyine: Rams -186, 49ers +156
The Rams started off as bigger favorites but as the week has progress, the number has dropped to near a field goal given some developments, including the 49ers looking healthier and the Rams losing key wide receiver Robert Woods to a season-ending torn ACL over the weekend.
(betting odds per FanDuel Sportsbook)
49ers vs. Rams all-time series
The 49ers still lead the rivalry 73-67-3. They’ve increased their advantage by winning four consecutive games, sweeping the Rams in both 2019 and 2020. Before that, the Rams had won three of four matchups. The last three meetings have been decided by one possession.
Three trends to know
—88 percent of bettors like the 49ers to cover the spread as road night underdogs, given how much better their offense is playing of late.
—56 percent of over/under bettors think the high point total is still not enough because of the potential of two potent offenses.
—The Rams are 4-6 against the spread and 7-3 straight up in their past 10 games including playoffs. The total has gone over in 6 of those games. The 49ers are 4-6 SU and ATS in the past 10 games. The total also has gone over in 6 of those games.
Three things to watch
How much will OBJ play?
Without Woods and with Beckham still learning the playbook, expect the Rams to feature a lot of Cooper Kupp and Van Jefferson at wide receiver, also getting tight end Tyler Higbee more involved. They also should incorporate their backs more in the passing game.
Will the 49ers run the ball well?
Mitchell has been getting better all-around with his rushing and receiving as a rookie. Now that the passing game is more dangerous with Kittle, Samuel and Aiyuk, the 49ers can turn back to their bread and butter as an extra support to their struggling defense. The ground performance will keep them in the game.
Who will rebound better, Stafford or Jimmy G?
Stafford had his worst game of the season against the Titans, throwing a pick six. Garoppolo made some big plays but also had turnovers against the Cardinals. Count on Stafford overworking a depleted secondary vs. Garoppolo facing Jalen Ramsey and Aaron Donald.
Stat that matters
131.6. That’s how many rushing yards on average the 49ers have given up per game, No. 26 in the NFL. Down Woods and breaking in Beckham, the Rams need to be focused on running on San Francisco with the combination of Darrell Henderson and Sony Michel. It also would take big pressure off the pass protection and Stafford, while also playing keep away from Shanahan’s potent offense.
49ers vs. Rams prediction
The Rams won’t run away from their division rivals. The 49ers are too well-coached to keep fading at home, where they have had major trouble winning at any time of day of late. Except a typical divisional grind of a game as the offensive outputs will be made closer with the weapons more even.
Rams 24, 49ers 20